Physical Activity, Television Viewing Time, and DNA Methylation in Peripheral Blood

EH Van Roekel; PA Dugué; CH Jung; JE Joo; E Makalic; EM Wong; DR English; MC Southey; GG Giles; BM Lynch; RL Milne

Journal article

Physical Activity, Television Viewing Time, and DNA Methylation in Peripheral Blood

EH Van Roekel, PA Dugué, CH Jung, JE Joo, E Makalic, EM Wong, DR English, MC Southey, GG Giles, BM Lynch, RL Milne

Medicine and Science in Sports and Exercise | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019

DOI: 10.1249/MSS.0000000000001827

Abstract

Introduction Physical activity may affect health via DNA methylation. The epigenetic influences of sedentary behaviors such as television viewing are unknown. We performed a genomewide study of DNA methylation in peripheral blood in relation to physical activity and television viewing time. Methods DNA methylation was measured using the Illumina Infinium HumanMethylation450K BeadChip array in blood samples collected at baseline (N = 5513) and follow-up (N = 1249) from participants in the Melbourne Collaborative Cohort Study. At baseline, times per week of leisure-time physical activity were self-reported. At follow-up, the International Physical Activity Questionnaire was used to assess MET-..

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University of Melbourne Researchers

Pierre-Antoine Dugue Author

Chol-Hee Jung Author

Eric Joo Author

Enes Makalic Author

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Grants

Awarded by Australian Education International, Australian Government

Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (NHMRC) (grant no. 1088405). MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by the Australian NHMRC grant nos. 209057 and 396414 and by infrastructure provided by the Cancer Council Victoria. Cases were ascertained through the Victorian Cancer Registry and the Australian Cancer Database (Australian Institute of Health and Welfare). The nested case-control methylation studies were supported by the NHMRC grant nos. 1011618, 1026892, 1027505, 1050198, 1043616, and 1074383. EHvR was supported by an Endeavour Research Fellowship from the Department of Education and Training of the Australian Government (60592017). MCS is an NHMRC Senior Research Fellow (1061177). BML is funded by a National Breast Cancer Foundation Fellowship (ECF-15-012). The study sponsors were not involved in the study design; in the collection, analysis, and interpretation of the data; in the writing of the report; and in the decision to submit the article for publication. The results of the present study do not constitute endorsement by the American College of Sports Medicine.